ABSTRACT
OBJECTIVE@#To explore the therapeutic effect and mechanism of acupoint catgut embedding for chloasma in premenopausal women with liver stagnation.@*METHODS@#A total of 92 patients of chloasma in premenopausal women with liver stagnation were randomized into an observation group and a control group, 46 cases in each one.In the observation group, acupoint catgut embedding was applied at Ganshu (BL 18), Pishu (BL 20), Sanyinjiao (SP 6), also the surrounding acupuncture was performed at facial part, once a week. In the control group, vitamin C (200 mg per time, 3 times a day) and vitamin E (100 mg per time, once a day) were prescribed for oral administration. Both of the two groups were given treatment for 12 weeks. The score of chloasma area and severity index (MASI), the serum levels of follicular stimulating hormone (FSH), leuteinizing hormone (LH) and estradiol (E) before and after treatment were observed in the two groups, and the clinical effect of the two groups were compared after 3 months of treatment.@*RESULTS@#Finally, 44 cases in the observation group and 43 cases in the control group completed the study. The effective rate in the observation group was 88.6% (39/44), which was higher than 55.8% (24/43) in the control group (0.05). There was no significant difference between before treatment and in follow-up in the levels of FSH, LH and E in the control group (>0.05). In follow-up, the levels of FSH and LH in the observation group were lower than the control group (0.05).@*CONCLUSION@#Acupoint catgut embedding can improve the clinical symptoms of chloasma in premenopausal women with liver stagnation, the mechanism may be related to regulate the serum level of sex hormone to reduce high sensitivity of melanocytes to estrogen.
Subject(s)
Female , Humans , Acupuncture Points , Acupuncture Therapy , Catgut , Liver , Melanosis , Therapeutics , QiABSTRACT
Introducción: Melasma es un trastorno adquirido, caracterizado por la aparición de máculas simétricas de color marrón, principalmente en áreas fotoexpuestas (centrofacial, malar y mandibular). Esta condición tiene potencial efecto sobre la autoestima y calidad de vida de quien lo porta. Objetivo: evaluar el efecto del Láser Fraxel Dual 1927 como tratamiento del melasma. Pacientes y método: revisión retrospectiva de fichas clínicas y fotografías de pacientes mujeres con melasma tratadas con 1 dosis de Láser Fraxel Dual 1927 entre los años 2010 y 2011 en el Centro Dermatológico de Clínica Las Condes. Se obtuvieron de las fichas clínicas la edad, género, fototipo de piel y niveles de energía utilizados. Se tomaron fotografías antes y después de la sesión de láser y se aplicó el score de severidad de melasma, previamente validado ( MASI modificado). Resultados: se estudiaron 10 pacientes mujeres, cuyo promedio de edad fue de 37.5 años (DE 5,15).Luego de la sesión con láser, se evidenció una disminución significativa del score MASI de 6.78 (DE 4,84) a 5.09 (DE 4,81) (p= 0.049). Conclusiones: nuestros resultados sugieren que el Laser Fraxel Dual 1927 sería una alternativa efectiva en el tratamiento del melasma. Por lo anterior, es necesario realizar nuevos estudios prospectivos para comprobar estos hallazgos y evaluar efectos adversos.
Background: Melasma is an acquired disorder, characterized by the appearance of symmetric brown patches, mainly on sunlight exposed areas of the face (midfacial, malar and mandibular areas). This condition could eventually impact on patients self-esteem and quality of life, encouraging the search for an effective therapy. Objective: To determine the effect of Fraxel Dual 1927 laser as treatment for melasma. Patients and method: Clinical records and pictures of patients with melasma treated with Fraxel Dual 1927 laser between 2010 and 2011 at the Dermatology Department of Clínica Las Condes, were retrospectively reviewed. Data related with age, gender, skin Fitzpatrick´s phototype, treatment energy and level used were registered from clinical records. Photos were taken before and after the laser treatment session and a previously validated severity score (modified MASI Score) was applied. Results: 10 female patients with a mean age 37.5 years old (SD 5.15 years) were studied. After laser therapy, there was evidence of statistically significant reduction of MASI score from 6.78 (SD 4.84) to 5.09 (SD 4.81) (p=0.049). Conclusions: Our results suggest Fraxel Dual 1927 laser as an effective alternative to treat melasma. It would be necessary to carry on new prospectives studies to ratify these findings and assess adverseeffects.